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Drugs Resistance Mechanisms

Some microbes respond predictably to certain drugs making selection of treatment easy. Other microbes may vary in their responses, and laboratory tests are usually required to ensure that the selected therapy is appropriate.

Chemotherapeutic effectiveness depends upon the sensitivity of the pathogen to the agent. Antibiotic resistance, however, may develop in microbes within the population. In fact, the history of chemotherapy has been closely paralleled by the history of drug resistance.

None of the therapeutic drugs (antibiotic) inhibits all microbial pathogens and some microbial pathogens possess natural ability to resist to certain antibiotics.

Bacteria become drug resistant using several different resistance mechanisms. A particular type of resistance mechanism is not confined to a single class of drugs. Two bacteria may employ different resistance mechanisms to counter the same antibiotic.

However, bacteria acquire drugs resistance using resistance mechanisms such as reduced permeability to antibiotic, efflux (pumping) antibiotic out of the cell, drug inactivation through chemical modification, target
modification and development of a resistant biochemical pathway (Figure 3.5).
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